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Journals and Conferences
A new method for synthesizing 17β-amino-5α-androstane was developed based on tigogenin. The configuration at C-17 was proved by PMR.
A series of new isonicotinylhydrazones and thiosemicarbazones of various ketosteroids was synthesized. The structures of the compounds were confirmed by NMR and IR spectroscopy and mass spectrometry.
One of the characteristic features of the structure of corticosteroids is the presence of a hydroxyl or a keto group at the ll-position of the steroid molecule.. The problem of the synthesis of corticosteroids from the commonly used steroid raw material with an unsubstituted ring C (diosgenin and soiasodin) has already been solved by microbiological… (More)
In the present work, we synthesized in a similar way 3e-hydroxy-5=-androst-9(ll)-en-17one (VI) from 38-acetoxy-5=-andros~an-17-one (I), which is also a transformation product of tigogenin , and studied the subsequent conversion of VI into llS,17B-dihydroxy-17~-methyl9=-fluoro-5=-androstan-3-one (XIII) and… (More)