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The expression of vascular endothelial growth factor (VEGF) has been described to coincide both temporally and spatially with angiogenesis suggesting a role as a paracrine stimulator of endothelial cells. We have used digoxigenin labelled RNA probes to VEGF and the VEGF receptor-2 (Quek1) to investigate the relationship between VEGF expression and vascular(More)
The local mechanical properties e.g. flow stress and fracture strain in an automotive component manufactured by deep drawing are inhomogeneous due to different local deformation degrees which affect the component behavior under crash loading. A reasonable approach for modelling the deformation and damage behavior of a component produced by deep drawing is a(More)
Several investigations have shown limitations of fMRI reliability with the current standard field strengths. Improvement is expected from ultra highfield systems but studies on possible benefits for cognitive networks are lacking. Here we provide an initial investigation on a prominent and clinically highly-relevant cognitive function: language processing(More)
Because of weight reduction necessities, high-strength steels are more and more widely used in bodyin-white (BiW) structures in recent years. Concerning the behaviour of such structures during a car crash the joints between high-strength materials are seen as critical points. Therefore the properties of welded joints, especially the failure behaviour at(More)
The increasing demands with regard to the predictive capabilities and the exactness of crash simulations require more and more investigations into numerical models in order to capture the physical behavior reliably. Steps towards this goal are the usage of finer meshes which allow for a better geometrical representation and more sophisticated material(More)
This paper presents the extension and validation of the damage model GISSMO (Generalized Incremental Stress State dependant damage MOdel). The damage model is extended for 3D usage by utilization of Lode angle parameter. The fracture strain is defined in the stress triaxiality and Lode angle parameter space as a surface. The fracture strain definition is(More)
(EEG) from unmedicated children strictly classified as unprovoked typical (3 c/s) absence seizures were selected. The dynamics of spike-and-wave discharges (SWD) were then examined by means of autocorrelation, correlation dimension, averaged pointwise dimension and largest Lyapunov exponent. For one EEG signal with pronounced spike-and-wave (SW) patterns,(More)
The essential function of vascular endothelial growth factor (VEGF) in embryonic angiogenesis has clearly been documented in murine embryos with targeted deletions of either VEGF or its receptors. The effects of VEGF in the organogenetic phase of development have not been studied to date. Therefore, we applied 0.7 to 0.9 microgram of VEGF via(More)
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