M F Wiser

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This paper presents a case study of 3-to 9-year-old children's concepts of size, weight, density, matter, and material kind. Our goal was to examine two claims: (1) that individual concepts undergo differentiation during development ; and (2) that young children's concepts are embedded in theory-like structures. To make progress on the first issue, we(More)
The malarial parasite dramatically alters its host cell by exporting and targeting proteins to specific locations within the erythrocyte. Little is known about the mechanisms by which the parasite is able to carry out this extraparasite transport. The fungal metabolite brefeldin A (BFA) has been used to study the secretory pathway in eukaryotes. BFA(More)
The merozoite surface protein-1 (MSP-1) is a relatively abundant protein which has been found in all Plasmodium species examined [1,2]. MSP-1 is synthesized as a high molecular mass (200 kDa) precursor protein which is proteolytically processed into smaller fragments. Proteolytic processing of MSP-1 is a two-step procedure characterized by primary and(More)
Proteases appear to be required for critical events in the erythrocytic life cycle of malaria parasites, including the rupture of erythrocytes by mature schizonts and the subsequent invasion of erythrocytes by daughter merozoites [1,2]. This conclusion is supported by studies showing that parasite rupture and invasion of erythrocytes are inhibited by serine(More)
The complete gene for merozoite surface protein-1 (MSP-1) from Plasmodium berghei has been cloned and sequenced. Comparison of the P. berghei MSP-1 sequence with MSP-1 from other rodent parasites reveals five conserved domains interrupted by four variable blocks. These variable blocks exhibit no sequence homology but do have similar amino acid compositions.(More)
The malaria parasite extensively modifies the host erythrocyte. Many of these modifications are mediated by proteins exported from the parasite and targeted to specific locations within the infected erythrocyte. However, little is known about how the parasite targets proteins to specific locations beyond its own plasma membrane. Treatment of infected(More)
Several highly antigenic proteins containing tandem repeats rich in glutamic acid residues have been described in Plasmodium falciparum. However, relatively little information is available about analogous genes in rodent parasites. This report describes a 4.2-kb genomic DNA fragment from P. chabaudi with a deduced amino acid sequence that is predominantly(More)
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