M F Mineyeva

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Electrical stimulation of rat hypothalamic synaptosome suspensions produced activation of tyrosine hydroxylase due to increase of the affinity for tyrosine and 6,7-dimethyl-5,6,7,8-tetrahydropterine cofactor, decrease of the affinity for dopamine and enhancement of substrate inhibition. Cocaine (10(-7) - 10(-5) M) in vitro caused enzyme activation; when(More)
E Summary. In experiments on gnaptosomes /rom rat b ain bypothalamus the effect o/ the actiuation of the pregna tic membrane by dopanine on the kinetic properties o j t rosine bydroxybse (TH) isolated from those synptosomes s studied. O w result~ indicute that the decrease o/ the rate o/ D O P A s nthesis during the actiuation of presynaptic receptors by d(More)
A new route for operating affinity biosensors based on the voltammetric monitoring of the accumulated guest (analyte) is described. High sensitivity and selectivity accrue from the coupling of the specific receptor binding process and the inherent sensitivity of the preconcentration/pulse-voltammetric scheme. The redox (measurement) process results in(More)
The effect of a number of neuroleptics and tricyclic antidepressants on the activity of rat hypothalamic tyrosine hydroxylase was studied utilizing a direct spectrophotometric method. All the neuroleptics (but not the antidepressants) were able to reverse the substrate inhibition of the enzyme occurring when the tyrosine concentration in the medium was(More)
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