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The blood-brain barrier (BBB) restricts the entry of antiviral agents into the CNS thereby facilitating the creation of a reservoir of HIV that could potentially reinfect peripheral tissues. We characterized the efflux from brain of radioactively labeled viral coat HIV-1 gp120 (I-gp120) after intracerebroventricular (i.c.v.) injection. The half-time(More)
Insulin found in the CNS may be a key regulator in the balance of energy in the body. Since the peripheral circulation is the principal source of insulin in the CNS, insulin must cross the blood-brain barrier. We examined the retention of radioactively labeled insulin in the brain and its transport from the brain after injection icv in mice. The results(More)
The muscarinic receptor blocker, scopolamine, inhibits the display of lordosis behavior in female rats but its effectiveness depends on hormonal conditions. In these experiments, systemic administration of scopolamine (0.031-4 mg/kg) inhibited lordosis in ovariectomized rats brought into receptivity by treatment with a low dose of estradiol benzoate (EB,(More)
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