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The morphology of the retinal blood vessels can be an important indicator for diseases like diabetes, hypertension and retinopathy of prematurity (ROP). Thus, the measurement of changes in morphology of arterioles and venules can be of diagnostic value. Here we present a method to automatically segment retinal blood vessels based upon multiscale feature(More)
PURPOSE To test the hypothesis that early rod dysfunction predicts the blood vessel abnormalities that are the clinical hallmark of retinopathy of prematurity (ROP). METHODS Two rat models of ROP, induced by exposure to alternating 50%/10% oxygen (50/10 model) from postnatal day (P) 0 to P14, or exposure to 75% oxygen (75 model) from P7 to P14, and(More)
A semi-automatic method to measure and quantify geometrical and topological properties of continuous vascular trees in clinical fundus images is described. Measurements are made from binary images obtained with a previously described segmentation process. The skeletons of the segmented trees are produced by thinning,ff branch and crossing points are(More)
PURPOSE To evaluate a semiautomated image analysis software package, Retinal Image multiScale Analysis (RISA), for the diagnosis of plus disease in preterm infants with retinopathy of prematurity (ROP). METHODS Digital images of the posterior pole showing both disc and macula in preterm infants with ROP were analyzed with an enhanced version of RISA.(More)
OBJECTIVE To measure accuracy and reliability of the computer-based Retinal Image Multiscale Analysis (RISA) system compared with those of recognized retinopathy of prematurity (ROP) experts, for plus disease diagnosis. DESIGN Evaluation of diagnostic test or technology. PARTICIPANTS Eleven recognized ROP experts and the RISA image analysis system(More)
We describe an improved implementation of a segmentation method for retinal blood vessels based on a multi-scale approach and region growing employing modules from the Insight Segmentation and Registration Toolkit (ITK). We present the results of segmentation of retinal blood vessels using this improved method and compare these with results obtained using(More)
OBJECTIVE Hypertension causes arteriolar narrowing and rarefaction in the retinal circulation, but the extent to which these changes are reversible by antihypertensive treatment is not well studied. We compared the effect of antihypertensive treatment with a calcium-channel-blocker-based regimen and an angiotensin-converting-enzyme-inhibitor-based regimen(More)
This paper presents a parallel implementation based on insight segmentation and registration toolkit for a multiscale feature extraction and region growing algorithm, applied to retinal blood vessels segmentation. This implementation is capable of achieving an accuracy (Ac) comparable to its serial counterpart (about 92%), but 8 to 10 times faster. In this(More)