M. E. van Royen

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Time-lapse fluorescence microscopy imaging has rapidly evolved in the past decade and has opened new avenues for studying intracellular processes in vivo. Such studies generate vast amounts of noisy image data that cannot be analyzed efficiently and reliably by means of manual processing. Many popular tracking techniques exist but often fail to yield(More)
Fluorescent protein labelling, as well as impressive progress in live cell imaging have revolutionised the view on how essential nuclear functions like gene transcription regulation and DNA repair are organised. Here, we address questions like how DNA-interacting molecules find and bind their target sequences in the vast amount of DNA. In addition, we(More)
In pathology the diagnosis of the disease state is typically done on 4-5 μm thin tissue 2D slides. Particularly in prostate cancer, this is known to be difficult from such thin slides, as the cancer growth is three dimensional. This has led to 3D studies of intact prostate biopsies with the aim of getting a more reliable assessment of the disease state as(More)
The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 5 599–613 www.jcb.org/cgi/doi/10.1083/jcb.201405014 JCB 599 *M. Reuter and A. Zelensky contributed equally to this paper. Correspondence to Claire Wyman: c.wyman@erasmusmc.nl Abbreviations used in this paper: ACF, autocorrelation function; CDF, cumulative distribution function; DSB,(More)
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