M E Tenneson

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detection reagents used (exposure to T2 vapour, reaction with rhodamine B, fluorescence under U.V. light and photolytic decomposition to give a dark spot on prolonged exposure to U.V. light at 254nm). When analysed by gas chromatography on a 1.5m column of 3 % OV-1 on 100-120 mesh diatomite in a Pye 104 gas chromatograph, a component was observed with the(More)
Microbial transformation of bile acids at the 3a-, 7aand 12a-hydroxyl positions, under anaerobic conditions, was first reported in Alcaligenes fueculis (Hughes & Schmidt, 1942). Other gut bacteria have also been shown to contain hydroxy steroid dehydrogenases (Aries & Hill, 1970). The most common of the three reactions, 7a-hydroxy steroid dehydrogenation,(More)
The effect of hydralazine on the pharmacokinetics of metoprolol, nadolol, and acebutolol has been studied by measuring drug concentrations in plasma, serum, and urine. Metoprolol is affected by hydralazine, the AUC and Cmax being significantly increased. The kinetics of acebutolol and its major metabolite, diacetolol, are unaffected. Poor absorption of the(More)
Reports on the microbial degradation of bile-acid conjugates have been mainly limited to observations of hydrolytic cleavage yielding free bile acids. Clostridium spp., Enterococcus spp. (Norman & Grubb, 1955), Bacteroides spp., BiJdobacteria spp. (Drasar & Hill, 1966) and species of rat intestinal bacteria (Dickinson et a/., 1971) were all shown to(More)
The microbial degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590 was studied, and two major products were isolated and identified as 7 alpha, 12 beta-dihydroxyandrosta-1,4-diene-3,17-dione and 7 alpha, 12 alpha-dihydroxy-3-oxopregna-1,4-diene-20-carboxylic acid. Four minor products were isolated and evidence is given for the following structures:(More)