M E Ostensen

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The effect of recombinant tumor necrosis factor-alpha (rTNF alpha) on human natural killer (NK) function was examined. Lysis of both the NK-sensitive K562 erythroleukemia line and the relatively insensitive renal carcinoma line Cur by nonadherent peripheral blood lymphocytes was significantly enhanced as a result of an 18-hr preincubation with either rTNF(More)
The current studies examined the potential for additive or synergistic augmentation of human natural killer (NK) function by combined stimulation with tumor necrosis factor alpha (TNF-alpha) or interleukin-1 (IL-1) and interferon-alpha (IFN-alpha) or IL-2. The modest augmentative effect of preincubation with either IL-1 or TNF-alpha alone was most(More)
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