M. E. Kucherenko

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Experiments on rats established that tRNA of the liver under the effect of total X-irradiation (800 R), nicotinic acid and neostigmine methylsulphate proves to be hypermethylated. In this case tRNA molecules undergo conformation changes. Nicotinic acid and neostigmine methylsulphate administered to the animals under experiment an hour before irradiation(More)
The content and methylation of total phospholipids in the brain, liver and muscles and some of their fractions obtained by the method of thin-layer chromatography on silicic acid were studied as affected by nicotinic acid. It is established that nicotinic acid in a dose of 20 mg/kg 4 hrs after subcutaneous injection evokes an increase in the content of(More)
It is established that 24 hours after total X-ray irradiation by doses of 0.5, 1 and 2 Gy activity of intestine enzymes (saccharose and alpha-amylase) increases. A dose of 3 and above induces an increase of saccharose activity and inhibition of alpha-amylase. The functional state of basic phosphatase under action of the doses investigated remains(More)
It has been shown, that the total X-ray irradiation in the dozes of 0.5 and 1 Gy influences on the content of lipid peroxidation products and enzymatic activity of antioxidant system in rat spleen and thymus cells. The influence of preparations "AMMIVIT" and "Ceruloplasmin" on these processes is investigated also. So, the animals feeding by the vitamin(More)
The content and specific activity of labelled methyl groups of choline and phosphorylcholine in the brain, liver and skeletal muscles of rats was studied as affected by nicotinic acid and prozerin, injected subcutaneously 4h before decapitation. It was found that under the effect of prozerin the specific activity of choline lowers only in the muscles and(More)
The primary biochemical and conformational changes in tRNA of the albino rat liver were studied under conditions of X-ray irradiation and under the effect of prozerine and nicotinic acid. Under the effect of these factors the rate of the liver tRNA methylation increases by 45, 103 and 112%, respectively. The melting point of the tRNA control preparations is(More)
The data are presented on the effect of activation of by peptidoglycans from cell walls of Staphylococcus aureus and Brevibacterium flavum on the DNA synthesis intensity in the mice spleen, thymus and bone marrow in vivo. Maximum of the peptidoglycan influence on the DNA synthesis intensity is observed 12-36 hours after injection. As a rule, higher doses of(More)
It was established that single total X-ray irradiation in the doses of 0.1; 0.4; 1.0; 2.0; 3.0 and 6.0 Gy 24 hours after irradiation results in reliable changes in membrane lipids composition of brush border of enterocytes in doses over 1.0 Gy. By this changes under increase of dosage of irradiation it were marked differences in comparison with control in(More)
Recent investigations using Scatchard plots, electrophoresis, and current-voltage characteristic curves have demonstrated that plasma membranes (PM) of skeletal, cardiac, and smooth muscles, leukocytes and hepatocytes, nerve and kidney tissue cells, and brush-border, placental, and other cells possess Ca-binding capacity [2, 5, 8]. However, until recently,(More)
In this review we summarize and generalize the recent data on structure, regulation and physiological role of calcium/calmodulin-dependent protein kinases, or CaM kinases. CaM kinases are the family of structurally homologous enzymes, involved into a variety of Ca(2+)-induced cellular reactions through phosphorylation of target proteins. In recent years the(More)
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