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Speech sounds are said to be perceived categorically. This notion is usually operationalized as the extent to which discrimination of stimuli is predictable from phoneme classification of the same stimuli. In this article, vowel continua were presented to listeners in a four-interval discrimination task (2IFC with flankers, or 4I2AFC) and a classification(More)
Glucocorticoids (GCs) secreted after stress reduce adult hippocampal neurogenesis, a process that has been implicated in cognitive aspects of psychopathology, amongst others. Yet, the exact role of the GC receptor (GR), a key mediator of GC action, in regulating adult neurogenesis is largely unknown. Here, we show that GR knockdown, selectively in newborn(More)
Early life is a period of unique sensitivity during which experience can confer enduring effects on brain structure and function. During early perinatal life the quality of the surrounding environment and experiences, in particular the parent-child relationship, is associated with emotional and cognitive development later in life. For instance, adverse(More)
Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex(More)
In the brain, the connection between sensory information triggered by the presence of a stressor and the organism's reaction involves limbic areas such as the hippocampus, amygdala and prefrontal cortex. Consequently, these brain regions are the most sensitive to stress-induced changes in neuronal plasticity. However, the specific effects of stress on(More)
VC transitions have often been found to be better cues for the identification of deleted consonants than CV transitions. The lower score for CV transitions could very well be due to an interfering "click sensation" caused by the abrupt begining of these transitions. In the present investigation the abrubt onset was eliminated by replacing the deleted(More)
On the basis of a number of vowel and stop-consonant discrimination experiments (AX and 2IFC fixed and roving) with natural stimuli, it is concluded that stop-consonant perception is highly categorical: there were few significant differences between the discrimination results and the phoneme identification results. Moreover, the discrimination and(More)
Recently we have shown that liposomes can be used as artificial microbes for the production and delivery of DNA-encoded antigens. These so-called antigen-expressing immunostimulatory liposomes (AnExILs) were superior in inducing antigen-specific antibodies compared to conventional liposomal protein or DNA vaccines when tested in mice after i.m.(More)
Adult neurogenesis generates functional neurons from neural stem cells present in specific brain regions. It is largely confined to two main regions: the subventricular zone of the lateral ventricle, and the subgranular zone of the dentate gyrus (DG), in the hippocampus. With age, the function of the hippocampus and particularly the DG is impaired. For(More)