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The present study provides the first demonstration that alterations of immune status can be conditioned to environmental stimuli paired with morphine administration. In the first manipulation, male Lewis rats received 0, 2, 4, 8 or 16 conditioning sessions during which a subcutaneous injection of morphine (15 mg/kg) was paired with a distinctive(More)
Although there is evidence to suggest that morphine can alter immune status, there is little information about the doses at which these effects occur, the extent of the immune alterations and whether morphine's immunomodulatory effects can be antagonized in a dose-dependent manner by an opioid antagonist. To address these issues, morphine (0, 5.0, 10.0,(More)
Developmental neurotoxicity may be influenced by effects of a compound on endocrine function. Here we report that developmental exposure to TMT increases the corticosterone (CS) response to stress in developing rat pups. Long-Evans rat pups were injected i.p. with either 6 mg/kg TMT hydroxide (in 10 microliters/g BW NaCl) or vehicle on Postnatal Day 5(More)
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