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The innervation of developing mouse teeth between initial formation and crown formation was investigated using silver-stained serial sections. The developing innervation correlated with the stage of development of individual teeth rather than the chronological age of the mice. Nerves approached the developing dental papilla during the bud stage and formed a(More)
During development axons contact their target tissues with phenomenal accuracy but the mechanisms that control this homing behaviour remain largely elusive. A prerequisite to the study of the factors involved in hard-wiring the nervous system during neurogenesis is an accurate calendar of developmental events. We have studied the maxillary and mandibular(More)
Following sciatic nerve axotomy, vasoactive intestinal polypeptide (VIP) immunoreactivity increases dramatically in the central terminal areas of the nerve whereas other primary afferent neuropeptides are depleted. The contribution of the peripheral nerve to VIP increases in the spinal cord was investigated by performing sciatic nerve section alone, dorsal(More)
The dental follicle and papilla are innervated at different stages of tooth development. The type of nerves innervating these structures at different stages was investigated using an enzymic method for acetylcholinesterase (AChE) and direct visualization for noradrenaline on fetal and neonatal stages up to 7 days after birth. Glandular and muscular tissue(More)
In an attempt to improve the safety of the submandibular approach to the mandible and submandibular anatomical dissections of 100 facial halves were undertaken. Observations were made on the course of the cervical branch of the facial nerve in relation to bony and soft tissue landmarks and fascial planes. The course of the nerve and its relation to the(More)
Somatotopic projections of each maxillary molar tooth were defined by injecting individual teeth with True blue and plotting the location of fluorescent cells in sections of the trigeminal ganglia. Collateral branching was investigated by injecting True blue and Diamidino yellow into pairs of maxillary molar teeth and examining the ganglia for double(More)
Following peripheral axotomy, fluoride resistant acid phosphatase (FRAP) and most neuropeptides are depleted in the central terminals of axotomised nerves and reduced in their corresponding cell bodies (DRG) but vasoactive intestinal polypeptide (VIP) increases. The increase in VIP probably results from a change in gene expression in other ganglion cells(More)
Peripheral nerve section or local capsaicin application produces depletion of substance P and an enzymatic marker, fluoride-resistant acid phosphatase (FRAP), from circumscribed regions of the terminal areas in the spinal cord. We have made use of this phenomenon to map the extent of central termination of subpopulations of primary afferent neurons(More)
In the vasoactive intestinal polypeptide (VIP)-rich lumbosacral spinal cord, VIP increases at the expense of other neuropeptides after primary sensory nerve axotomy. This study was undertaken to ascertain whether similar changes occur in peripherally axotomised cranial sensory nerves. VIP immunoreactivity increased in the terminal region of the mandibular(More)