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Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele(More)
Compelling biological and epidemiological evidences point to a key role of genetic variants of the TERT and TERC genes in cancer development. We analyzed the genetic variability of these two gene regions using samples of 2,267 multiple myeloma (MM) cases and 2,796 healthy controls. We found that a TERT variant, rs2242652, is associated with reduced MM(More)
The asymptotic theory of the distribution of the latent roots and vector of principal components analysis (PCA) of samples has hitherto been tied t multivariate normal (MVN) distributions. However, much real behavior dat are not normal. The results of the present study show, using arguments base on Monte Carlo methods, that if there is enough meaningful(More)
BACKGROUND Genetic background plays a role in multiple myeloma susceptibility. Several single-nucleotide polymorphisms (SNP) associated with genetic susceptibility to multiple myeloma were identified in the last years, but only a few of them were validated in independent studies. METHODS With the aim to conclusively validate the strongest associations so(More)
In 14 series, each of 100 tests, involving 350 individual animals it has been shown that odors derived from the anal, inguinal and chin glands and urine strengthen to different degrees the confidence of European wild rabbits,Oryctolagus cuniculus. In the tests, two rabbits were put together on otherwise neutral ground previously treated with the odor from(More)
The idiopathic hypereosinophilic syndrome (HES) comprises a heterogenous group of disorders characterized by marked blood eosinophilia with eosinophilia-associated organ damage. Eight patients with a median age at diagnosis of 42 years (range 19-67) received imatinib mesylate (IM) for FIP1L1-PDGFRα-negative HES resistant to previous conventional treatment.(More)
The aim of this paper is to present a new well-balanced finite volume scheme for two-dimensional multilayer shallow water flows including wet/dry fronts. The ideas, presented here for the two-layer model, can be generalized to a multilayer case in a straightforward way. The method developed here is constructed in the framework of the Finite Volume Evolution(More)