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Background—Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN). Methods and Results—We examined the role of IL-12 receptor (IL-12R) signaling in the development of murine experimental(More)
Intracellular accumulations of altered, misfolded proteins in neuronal and other cells are pathological hallmarks shared by many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Mutations in several genes give rise to familial forms of ALS. Mutations in Sigma receptor 1 have been found to cause a juvenile form of ALS and(More)
Für einen objektorientierten Informatikunterricht in der Jahrgangsstufe 11 spielen mentale Vorstellungen der Schüler zu den wichtigsten Grundbegriffen eine große Rolle. Zur Veranschaulichung zentraler Begriffe der Objektorientierung sind geeignete mediale Werkzeuge wie etwa das CASE-Tool FUJABA sicher sinnvoll, jedoch ergeben sich daraus zusätzliche(More)
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