M. Diaz

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Mutations in BEST1 gene, encoding the bestrophin-1 (Best1) protein are associated with macular dystrophies. Best1 is predominantly expressed in the retinal pigment epithelium (RPE), and is inserted in its basolateral membrane. We investigated the cellular localization in polarized MDCKII cells of disease-associated Best1 mutant proteins to study specific(More)
  • J. Cano-Parra, A. Duch, F. J. Iborra, C. Ruiz-Lapuente, A. Martinez-Palmer, A. Navea +1 other
  • 1995
PURPOSE. Light microscopic and ultrastructural studies were perfomed in the human epiretinal membranes secondary to proliferative vitreoretinopathy (PVR).HETRODS.Humanpreretinal membranes from 5 eyes with PVR were obtained by vitrectomy. These membranes were processed for inmunohistochemical (GFAP) and electron microscopy studies to study the morphology and(More)
P"rpse: To investigate the clinical and histological toxicity of the exposure of the :rabbit cornea1 endothelium to anterior chamber injection of liposome-encapsulated 5-fluorouridine (LS-FUR) at concentrations of 1 mg/ml and 0.38 mg/ml and intravitreal injection of I.5FUR at 1 mg/ml. M*thOdS : A total of 12 New Zealand white rabbits were divided in three(More)
  • J. Cano-Parra, A. Navea, C. Ruiz-Lapuente, A. Martinez-Palmer, M. Castilla, M. J. Gómez-Lechón +1 other
  • 1995
PURPOSE: We studied the effects of exposure to mitomycin C and 5-Fluorcuracil to human RPE cultures, in growth inhibition and citoxicity. METHODS: 1) Growth inhibition: RPE cultures (3.000 cells/well) were exposed to different concentrations of mitomycin C and 5-Fluorouracil, and cell viability (MTT test) was evaluated 48h, 72h and 96h after. 2)(More)