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The abdominal aortic aneurysm (AAA) is a common vascular disease. The current clinical criterion for treating AAAs is an increased diameter above a critical value. However, the maximum diameter does not correlate well with aortic rupture, the main cause of death from AAA disease. AAA disease leads to changes in the aortic wall mechanical properties. The(More)
The pulse-wave velocity (PWV) has been used as an indicator of vascular stiffness, which can be an early predictor of cardiovascular mortality. A noninvasive, easily applicable method for detecting the regional pulse wave (PW) may contribute as a future modality for risk assessment. The purpose of this study was to demonstrate the feasibility and(More)
I n the United States, aortic aneurysms are the 13th leading cause of death. 1,2 Approximately 15 000 individuals die every year because of the rupture of aortic aneurysms. On the basis of autopsy studies, it has been estimated that 1% to 2% of the population harbor aneurysms in their aorta, with up to 10% prevalence in older age groups. 1,2 Most aortic(More)
C ompanion reports in this issue of Circulation under the senior authorship of G.R. Upchurch 1,2 address the possible roles of polymorphonuclear (PMN) cells in the pathogenesis of the nonspecific abdominal aortic aneu-rysm (AAA). As the authors observe, the AAA is the 10th leading cause of death in white men ages 65 to 74, according to the 2000 National(More)
Elastin and reticular fibers were identified using standard histological strains in middle cerebral arteries taken from patients who had died from aneurysmal subarachnoid hemorrhage and control patients who did not have cerebral aneurysms. Examination of cerebral arteries from normal individuals revealed a dense network of fine reticular fibers in the(More)
—The abdominal aortic aneurysm (AAA) is a common vascular disease. AAA disease leads to changes in the mechanical properties of the aortic wall. Pulse-Wave Imaging (PWI) has been developed by our group to noninvasively and visually map the pulse-wave propagation along the aortic wall in mice at a frame rate of 8 kHz in vivo. By using a retrospective(More)
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