M David Jewell

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BACKGROUND A meta-analysis of observational studies have suggested that planned home birth may be safe and with less interventions than planned hospital birth. OBJECTIVES The objective of this review was to assess the effects of planned home birth compared to hospital birth on the rates of interventions, complications and morbidity as determined in(More)
A number of C4--C9 aliphatic ketones are acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) inhibitors, with Ki values in the 0.7--5 mM range. Comparison to analogous substrates would suggest that these ketones are transition state analogs; e.g. 2-pentanone binds to the enzyme approx. 550 times more tightly than ethylacetate. However, a number of(More)
At Southampton Medical School students in the third year of the course (the first clinical year) spend one morning a week in general practice. Discussion of patients' problems with students often encompasses ethical issues, and for some time we have been aware of our inability to provide any clear framework for an informed debate. Our students get some(More)
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