The experiments on albino rats demonstrated that antidepressants pyrazidol, imipramine, incazane, moclobemide and to a lesser degree azaphen reduce the amnesic effects of electroshock and scopolamine in the rats with the acquired conditioned reaction of passive avoidance. The studied antidepressants decrease also the disturbing action of alcohol on the… (More)
Tetrindol, a selective inhibitor of MAOA (predominantly of serotonin oxidase) and fluoxetine, an inhibitor of serotonin neuronal uptake, were studied in psychotropic tests on mice and rats. Both drugs significantly intensified 5-hydroxytriptophan-induced head twitching, reduced the effect of reserpine and the destructive action of maximal electroshock and… (More)
The antidepressive effects of tetrindole versus pyrazidole (pirlindole) and imipramine were studied in animal experiments. Tetrindole was found to be more active than pyrazidole and imipramine in a behavioral model of Porsolt, in antagonism with reserpine, in potentiation with 5-hydroxytryptophan, L-dopa and clonidine. The action of terindole is related to… (More)
In experiments on conscious normotensive male Wistar rats the new antidepressants, reversible MAO-A inhibitors, pyrazidole and incazane, as well as moclobemid increased the pressor effect of orally administered tyramine. The drugs potentiated also the pressor effect of intravenous tyramine. More prolonged potentiation of tyramine action was produced by… (More)
Experiments were performed on mice. Piracetam (500 mg/kg orally), but not meclofenoxate (100 mg/kg orally) potentiated the activating effect of antidepressants: pyrazidol, inkazane, nialamid and imipramine (10 mg/kg orally), in the "behavioral escape" test.
Effect of some MAO inhibitors on rotational behavior induced by d-amphetamine in unilaterally 6-OHDA-lesioned rats was studied. Among all MAO inhibitors tested only 1-deprenyl induced rotational behavior. Nialamide, chlorgiline, pyrazidol and inkazan dose-dependently enhanced rotational behavior induced by 2 mg/kg i. p. d-amphetamine and pargiline depressed… (More)
In experiments on unanesthetized rabbits it was found that the effects of ketamine and kalipsol were characterized by a decrease of the negative phase amplitude of the primary response (PR) of evoked potentials (EP) and the secondary positive deviation of EP of the cortical somatosensory region.
Inkazan and pyrazidol given to mice in certain doses were found to reduce the sedative action of diazepam without decreasing its anxiolytic effect but at the same time enhancing the anticonvulsive one. Imipramine diminishes the hypolocomotor action of diazepam and also its anxiolytic effect and exerts no influence on the anticonvulsive effect. All studied… (More)