M Cissé-Thiam

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Commercial aurin tricarboxylic acid (ATA) has been reported to interfere specifically with von Willebrand factor-glycoprotein Ib (vWF-GPIb) axis. This study was designed to explore the antithrombotic effects of ATA by examining its effects on guinea pig platelet function in vitro, in vivo and ex vivo. In vitro, addition of various concentrations of ATA to(More)
To experimentally evaluate the role of von Willebrand factor in thrombosis, a monoclonal antibody-712-, directed against the binding domain of von Willebrand factor to the platelet glycoprotein Ib and a control antibody D4H1, directed against the light chain of Factor VII C, were injected into guinea pigs. A model of experimental thrombosis induced by laser(More)
The antithrombotic activity of aspirin (acetylsalicylic acid), inhibitor of the synthesis of thromboxane A2 was compared to that of Bay U3405, a thromboxane A2 receptor antagonist. A model of experimental thrombosis induced by laser in guinea pig mesenteric arteries was used. Aspirin exhibited a dose-dependent antithrombotic activity with and inhibitory(More)
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