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Given that the rationale for empirical antifungal therapy in neutropenic children is limited and based on adult patient data, we performed a prospective, randomized, controlled trial that evaluated 110 neutropenic children with persistent fever. Those at high risk for invasive fungal infections (IFI) received caspofungin (Arm C) or liposomal amphotericinB(More)
In this paper we propose a nonparametric method, based on locally variable band-widths kernel estimators, to describe the space-time variation of seismic activity of a region of Southern California. The flexible estimation approach is introduced together with a diagnostic method for space-time point process, based on the interpretation of some second-order(More)