M Chicault

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Interactions of tetramisole, imidazo[2,1-b]thiazolic derived or immunomodulatory agents with human serum albumin (HSA) and immunoglobulins G and A has been investigated in vitro using polyacrylamide gel electrophoresis and immunoelectrophoresis. The results suggest that only the chemical structure type of tetramisole is able to induce a protein-protein(More)
In the present communication, a model is reported in order to explain the aggregation of albumin induced by levamisole in vitro. The hypothesis suggests that the process of polymerization of albumins may include ligand-protein interaction as a biochemical catalysis, and covalent protein-protein interactions by a mechanism of disulfide-sulfhydryl interchange(More)
The actions of (--)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole (levamisole) on human serum, human serum albumin (HSA) and bovin serum albumin (BSA) were studied. Analysis by polyacrylamide gel electrophoresis and immunodiffusion on gelose revealed the presence of aggregate forms of albumin in the human serum and a quantitative variation of polymeric(More)
Effects of two antirheumatic drugs, D-penicillamine and (-)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b] thiazole (levamisole), on some human serum proteins with specific function are reported. Drug effects on the interaction corticosterone-corticosteroid binding globulin (CBG) in vitro were investigated especially by polyacrylamide gel electrophoresis. A(More)
Comparative studies by polyacrylamide gel electrophoresis and immunoelectrophoresis showed that DL-2-oxo-3-(2-mercaptoethyl)-5-phenyl-imidazolidine (OMPI), a major metabolite of levamisole in vivo, exerted an inhibitory effect on the polymerization of albumin induced by levamisole action on human serum in vitro. Similar effects were obtained with sulfhydryl(More)
The chemical interaction of levamisole with human serum albumin (HSA) has been investigated using the technique of nuclear magnetic resonance spectroscopy. Binding to HSA occurs primarily with the imidazolidine and thiazolidine groups of levamisole as it has been demonstrated by selective changes in the relaxation times and the chemical shifts of the(More)
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