M Chadelaud

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A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration; pretreatment orally with cytidine diphosphocholine (CDP-choline) does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation. Levodopa antagonizes the oxotremorine-induced cerebral symptoms (akinesia + tremor); however this(More)
Ethanol preferring rats were selected and showed a constant voluntary intake of a 12% ethanol solution during 14 days (about 5 g/kg body weight daily). These alcohol preferring rats were daily IP injected during two weeks with different antidepressant drugs, according to their specificity of action: nomifensine (5 and 10 mg/kg) and maprotiline (2.5 and 5(More)
Six consanguine monogamous SHR couples (G1) were treated from 5 weeks of age on with an alpha blocker, nicergoline, 0.1 mg/kg/day i.p.. Male rats were treated without interruption; treatment was withheld in female rats from delivery to weaning. They were compare to six similar SHR couples who were only daily i.p. injected with the same volume of solvent in(More)
Ten consanguine monogamous SHR couples (G1) were treated from their 5th to their 37th week of age with captopril, 50 mg/kg/day i.p. Male rats were treated without interruption. Treatment was withheld in female rats from delivery to weaning. They were compared to ten similar SHR couples which were only daily i.p. injected with the same volume of solvent.(More)
RU 25960--3-[Bis(3,3-diphenylpropyl)-amino]-propan-1-ol hydrochloride--a vasodilator with calcium antagonist properties, was tested on learning in hypobaric hypoxic rats and survival time in normobaric hypoxic mice. It decreased learning in hypobaric hypoxia, but did not change survival time in mice. This suggests that the mechanisms underlying learning and(More)
Seven consanguine monogamous SHR couples (G 1) were treated from their 5th to their 39th week of age with prazosin, 100 micrograms/kg/day i.p. Male rats were treated without interruption. Treatment was withheld in female rats from delivery to weaning. They were compared to seven similar SHR couples who were only daily i.p. injected with the same volume of(More)
Six consanguine monogamous SHR couples (G 1) were treated from 5 weeks of age on with an alpha blocker, nicergoline, 100 mcg. kg-1 day-1 i.p. Male rats were treated without interruption; treatment was withheld in female rats from delivery to weaning. They were compared with six similar SHR couples who were only daily i.p. injected with the same volume of(More)
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