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We examined the axonal transport of two strains of herpes simplex virus 1 (HSV-1) within the central nervous system of cebus monkeys. Each strain was injected into the "arm area" of the primary motor cortex. One strain, HSV-1(McIntyre-B), was transported transneuronally in the retrograde direction. It infected neurons at sites known to project to the arm… (More)
Embryonic neostriatal cell suspensions were transplanted into intact or kainic acid-lesioned neostriata of adult host rats. These transplants survived and were sacrificed at 34-78 days posttransplantation. Nissl and Golgi preparations revealed neurons present within the transplants. Neurons with abundant dendritic spines (Spiny type I) were most frequent,… (More)
Dendritic spine density was determined quantitatively in 35-day-old neostriatal transplants and age-matched control tissue. Transplanted spiny I neurons showed significant decreases in spine density and in number of proximal dendrites. These differences may be due to aberrant maturation of transplanted neurons.