M C Clavequin

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Development of the paraventriculo-infundibular corticoliberin system was studied by immunocytochemical analysis of human hypothalamic sections using antisera raised against rat or ovine corticotropin-releasing factor (CRF). This comparative study confirms the presence of a significant number of CRF-immunoreactive fibers in the median eminence during the(More)
In the central nervous systems of several species belonging to different vertebrate classes, immunocytochemical stainings with an antiserum to ovine CRF 41 show multiple location of CRF perikarya and various areas containing CRF fibres and terminals. These stainings reflect species and interspecies functional adaptations of the CRF neurones which constitute(More)
In the human fetus, the first anti CRF-stained fibres appear in the median eminence during the 16th week. From the 17th week, they are more numerous and they establish neurohemal terminals close to the superficial capillaries and around some of the developing intra-eminential vascular loops. In new born infants infundibular CRF-containing processes and(More)
An antiserum raised against synthetic salmon melanin-concentrating hormone (MCH) reveals an extensive neuronal system in the posterior lateral areas of the human hypothalamus. These neurons correspond to those previously described in the rat, which are characterized by expression of MCH-like, alpha-melanotropin-like and human growth hormone-releasing factor(More)
Immunohistochemistry makes possible the in situ detection of neuropeptides in the cell bodies were they are synthesized, in the fibers that carry them, and in endings. Immunohistochemistry appears necessary to identify and map peptidergic neurons and to study their ontogeny. From 1975, we have carried the immunohistochemical study of several hypothalamic(More)
Human posterolateral hypothalamic neurons are revealed with an anti GRF 37 serum as soon as the 7th week of fetal life. The same neuronal population can be observed in the adult brain even in hypothalami from old subjects, with the same distribution, and similar immunoreactivity than in fetal stages. These neurons are revealed using a melanin concentrating(More)
A human GRF 1-37 antiserum demonstrates a new neuronal system in lateral perifornical areas of the human hypothalamus. The molecule that is revealed in those neurons cannot be somatocrinin. Perikarya are abundant. They are observed beginning with the 9th week of development. alpha-MSH-like immunoreactivity, which is showed in the analogous cells of the rat,(More)
In human fetus, newborn, infant and adult hypothalami, antibodies to ovine corticoliberin-41 stain a paraventriculo-infundibular neuroglandular pathway. The perikarya are located in the paraventricular nucleus, they mainly project to the ventral and lateral areas of the median eminence. Eminential corticoliberin-positive fibres appear during the 16th week(More)
Confrontations of immuno-stainings as well as sequential stainings with corticoliberin and vasopressin antisera were performed on contiguous sections of human median eminence (ME) or hypothalamic paraventricular nucleus (PVN). Results show that a double immunoreactivity to both IS is expressed in some parvicellular PVN perikarya, and suggest that such a(More)