Learn More
HYPOTHESIS Perioperative administration of a supplemented enteral formula may decrease postoperative morbidity. DESIGN Randomized clinical trial. SETTING Department of surgery at a university hospital. PATIENTS One hundred ninety-six registered malnourished patients (weight loss > or = 10%) who were candidates for major elective surgery for malignancy(More)
BACKGROUND Meta-analyses in the literature show that enhanced recovery after surgery (ERAS) is associated with lower morbidity rate and shorter hospital stay after elective colorectal surgery. However, a recent Cochrane review did not indicate the ERAS pathway as being the new standard of care due to the limited number of published trials, together with(More)
BACKGROUND Data on enhanced recovery programmes after pancreatic surgery are sparse. This retrospective cohort study, using historical controls, aimed to evaluate the impact of a fast-track programme after pancreaticoduodenectomy (PD). METHODS Between 2004 and 2007, 252 patients undergoing PD were treated by a fast-track programme that included earlier(More)
OBJECTIVE To evaluate the impact of the route of administration of artificial nutrition and the composition of the diet on outcome. DESIGN Prospective, randomized, clinical trial. SETTING Department of surgery, university hospital. PATIENTS One hundred sixty-six consecutive patients undergoing curative surgery for gastric or pancreatic cancer. (More)
Overexpression of mutated superoxide dismutase (SOD1) in transgenic mice causes a progressive motor neuron degeneration in the spinal cord similar to that in human amyotrophic lateral sclerosis (ALS). Ultrastructural analysis of motor neurons at different stages of the disease in transgenic C57BL/6 mice carrying the G93A mutation of SOD1 showed, at about 2(More)
INTRODUCTION A relaparotomy for a pancreatic fistula (PF) after a pancreaticoduodenectomy (PD) is a formidable operation, and the appropriate treatment of anastomotic leakage is under debate. The objective of this study was to compare the outcomes of different strategies in managing the pancreatic remnant during a relaparotomy for PF after a PD. METHODS(More)
Enhanced recovery of patients after surgery ("ERAS") has become an important focus of perioperative management. From a metabolic and nutritional point of view, the key aspects of perioperative care include: Enteral nutrition (EN) by means of oral nutritional supplements (ONS) and if necessary tube feeding (TF) offers the possibility of increasing or(More)
HYPOTHESIS Perioperative administration of a supplemented enteral formula may reduce the rate of postoperative infections. DESIGN Prospective, randomized, double-blind clinical trial. SETTING Department of surgery at a university hospital. PATIENTS Two hundred six patients with neoplasm of colorectum, stomach, or pancreas. INTERVENTION Patients were(More)
BACKGROUND & AIMS Perioperative nutrition with specialized enteral diets improves outcome when compared with standard formulas. A post-hoc analysis suggested preoperative administration as the most important period. Thus, we designed a study to understand prospectively whether preoperative supplementation could be as efficacious as the perioperative(More)
OBJECTIVE To study the effect of the route of delivery and formulation of postoperative nutritional support on host defense, protein metabolism, infectious complications, and outcome. DESIGN Prospective, randomized, clinical trial. SETTING Department of Surgery at a university hospital. PATIENTS Two hundred sixty candidates for pancreaticoduodenectomy(More)