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Various mutations in LMNA gene, encoding for nuclear lamin A/C protein, lead to laminopathies and contribute to over ten human disorders, mostly affecting tissues of mesenchymal origin such as fat tissue, muscle tissue, and bones. Recently it was demonstrated that lamins not only play a structural role providing communication between extra-nuclear(More)
In this paper, the theoretical sensitivity limit of the localized surface plasmon resonance (LSPR) to the surrounding dielectric environment is discussed. The presented theoretical analysis of the LSPR phenomenon is based on perturbation theory. Derived results can be further simplified assuming quasistatic limit. The developed theory shows that LSPR has a(More)
Patients with thyreotoxicosis have variable clinical manifestations and various degree of cardiomyopathy which severity depends on many factors. Last years the genetic factors predicting development and clinical features of thyrotoxic symptoms and thyreotoxic cardiomyopathy became more evident. It is known, that production of T3 in various tissues including(More)
We present a simulat ion platform which serves as an integrated framework for mu ltiscale and mu ltiphysics modeling of Organic Light Emitting Diodes (OLEDs) and their co mponents. The platform is aimed at the designers of OLEDs with various areas of expert ise ranging fro m the fundamental theory to the manufacturing technology. The platform integrates an(More)
At the present time, sorptional methods are widely used for the purification of vitamins [4-6]. The drawbacks of these methods include the long duration of the process, which is due to slow diffusion of large organic ions inside the sorbent grain [2]. The long d~ration of the process can lead to losses of rather unstable biologicallyactive compounds. One of(More)
Different methods including sorption processes, which already allow a significant decrease in the amount of the solutions being treated at the ftrst purification stage and a simplification in the management of the process especially when the sorbent is utilized repeatedly, are applied for the isolation and purification of vitamins obtained in the(More)
The coenzyme form of vitamin B12 (5,6-dimethylbenzimidazolyl)-Co-5'-desoxyadenosylcobamide or adenosylcobalamincoenzyme B12 is the main functional form in animals and microorganisms. The problem of the development of methods for the isolation of coenzyme B12 has basic significance since the commercial preparation of cyanocobalamin is utilized for its(More)