M. Beth Goens

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An in vitro receptor binding assay, using filtration to separate bound from free [125I]insulin, was developed and used to characterize insulin receptors on membranes isolated from specific areas of rat brain. The kinetic and equilibrium binding properties of central receptors were similar to those of hepatic receptors. The binding profiles in all tissues(More)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicity of xenobiotics, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Genetic deletion of the AhR leads to cardiac hypertrophy, suggesting a role for the AhR in cardiovascular physiology and disease; however, the pathways involved in the development of cardiac(More)
Cyclic variation of integrated backscatter (CVIBS) is altered in adults with myocardial infarction, allograft rejection, and cardiomyopathy. Its utility in children has not been tested. We studied 99 normal subjects: 16 fetuses, 13 newborns, 47 children, and 23 teenagers. Fifteen children with cardiomyopathy (13 dilated and two infiltrative) were studied to(More)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor characterized to play a role in detection and adaptation to environmental stimuli. Genetic deletion of AhR results in hypertension, and cardiac hypertrophy and fibrosis, associated with elevated plasma angiotensin II (Ang II) and endothelin-1 (ET-1), thus AhR appears to(More)
In utero and lactational exposure of mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to cardiac hypertrophy and hydronephrosis in adulthood. We tested the hypothesis that perinatal TCDD exposure increases the susceptibility to cardiovascular disease when offspring are exposed to a common cardiovascular disease risk factor, angiotensin II (Ang II).(More)
OBJECTIVE To describe a case of spontaneous chylothorax in a child with Noonan syndrome successfully treated with prednisone. DESIGN Case report. SETTING A pediatric cardiology referral center for the Rocky Mountain region. PATIENT An 18-month-old girl with Noonan's syndrome, pulmonary stenosis, and hypertrophic cardiomyopathy who presented with(More)
Acoustic quantification, a new ultrasound technique, provides a more direct assessment of the health of the myocardium than conventional echocardiography. Through software enhancements, acoustic quantification can characterize the myocardium as viable or nonviable, automatically track the endocardium throughout the cardiac cycle, and show myocardial(More)
Ebstein's anomaly is a rare congenital heart defect. Patients with severe symptomatic tricuspid regurgitation requiring surgical correction often have conduction system disease. We present a case of a 14 year-old girl with Ebstein's malformation and bioprosthetic tricuspid valve who required permanent pacing for symptomatic bradycardia. The placement of the(More)
The aryl hydrocarbon receptor (AhR) was originally characterized because of its high affinity binding of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. However, studies using AhR-null mice have demonstrated the importance of this protein in normal physiology and development. Here we demonstrate that AhR-null embryos develop cardiac enlargement, and that this(More)
OBJECTIVE Congenital heart disease (CHD) remains a significant cause of neonatal morbidity and mortality. This study evaluates the success of fetal echocardiography (FECHO) in guiding delivery management in pregnancies complicated by CHD. METHODS Cases with CHD diagnosed by prenatal FECHO performed at a single institution from January 2000 to June 2005(More)