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CONTEXT Lipotoxicity is a risk factor for developing obesity-related metabolic complications, including non-alcoholic fatty liver disease, type 2 diabetes (DM2), cardiovascular disease and stroke. Yet, the mechanisms underlying the development of lipotoxicity itself remain poorly understood. Here, we investigated whether glucose intolerance aggravates(More)
Allergen immunotherapy (AIT) is an effective treatment strategy for allergic diseases and has been used for more than 100 years. In recent years, however, the expectations on concepts, conduct, statistical evaluation and reporting have been significantly developed. Products have undergone dose-response and confirmative studies in adults and children to(More)
Methods Nasal secretions from 12 patients with AR to grass pollen and 12 healthy controls were collected. Two preweighed filter discs were placed bilaterally under direct visualization on the anterior third of the nasal septum. Five minutes later, they were removed and weighted again. After adding 2 ml 0,9% NaCl solution to the discs and centrifugation, the(More)
s from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017) Düsseldorf, Germany. 30 March–01 April 2017 Published: 23 August 2017 © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits(More)
Background There is evidence for local production of IgE in the nasal mucosa of patients with allergic rhinitis (AR). Collection of nasal secretions (NS) by validated methods for measurement of local IgE is of great interest. We aimed to compare two methods for collection of NS sinus packs (SP) and filter disks (FD) and to evaluate the suitability of using(More)
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