M Barbakadze

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It has been clinically established that epilepsy and depression frequently represent a comorbid pair. Most of investigators consider that epilepsy is a cause of emotional disorders such as anxiety and depression. On the other hand, some anti-epileptic drugs were found to aggravate depressive state, even to a suicide outcome. Bearing in mind these findings,(More)
This paper gives the results on the studies of the effect of multiple generalized seizures (MGSs) on the wakefulness-sleep cycle (WSC). The adult Wister rats served as the experimental objects. The animals, under chloral hydrate anesthesia (35-40mg/kg) were stereotaxically implanted with stainless metal electrodes aimed into the neocortex and dorsal(More)
Depressive disorders, which show ever increasing prevalence, urgently require relevant medications. In its turn search for the antidepressant drugs requires valid animal models of depression for a drug screening. The goal of the present study was construction of affordable and simple model of reactive depression in rats, which model could be implemented in(More)
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