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BACKGROUND The association between depression and pain, function, medically unexplained symptoms and psychophysiological syndromes such as irritable bowel syndrome has not been explored before in chronic fatigue syndrome. METHODS Cross-sectional controlled study of the current prevalence of psychophysiological syndromes, pain, function and lifetime(More)
Immunoregulatory cytokines have an influence on hepatitis C virus (HCV) infection outcome. This study aimed to determine whether single nucleotide polymorphisms (SNP) in IFN- γ and IL-10 genes are associated with susceptibility and/or are markers of prognosis regarding chronic hepatitis C outcomes. IFN γ (+874T/A) and IL-10 (-1082G/A) genotypes were(More)
BACKGROUND Bone marrow examination has been the confirmatory test for congenital dyserythropoietic anemia type II (CDAII). Occasional spherocytes on peripheral blood smear can confound the diagnosis. Since a screening test is still unavailable, we explored the feasibility of using flow cytometry as a preliminary screening method. METHODS Thirteen(More)
F1P1 V F 8 6.2 8.8 390 2 LM 1:1 ND CDA II band 3 Y462C/Y462C F2P1 V M 9 5.5 12.5 384 <0.2 LM 1:4 ND CDA II band 3 Y462C/Y462C F3P1 V M 6 10.8 6.4 368 0.4 LM 1:2 POS CDA II band 3 Y462C/Y462C F4P1 V M < 1 7.5 4.1 311 2.5 LM, EM 1:5 ND CDA II band 3 Y462C/Y462C F4P2 V M < 1 7.1 4.1 282 3.3 LM, EM 1:3 ND ND Y462C/Y462C F5P1a V M 21 8.4 3.2 301 2.6 LM, EM 1:3(More)
Energy intake and energy expenditure, nitrogen intake, and urinary nitrogen excretion (or urea production rates) were measured in 35 intravenously fed patients with multiple organ failure over the course of their illness to determine to what extent nutrient requirements were met despite fluid retention. Energy and nitrogen balance were related to serial(More)
The results of hepatitis C virus (HCV) antibody test of 237,813 blood donations collected from 143,815 donors by the West Midlands Blood Transfusion Centre in 1993 were analyzed retrospectively in order to determine the seroconversion rate among established previously anti-HCV negative donors. Three hundred sixteen (0.22%; 1 in 455) donors were positive by(More)
The significance of seroconversion as detected by an ELISA screening test for hepatitis C virus (HCV) antibody with a negative supplemental/confirmatory recombinant immunoblot assay (RIBA) result was investigated. Of 118,220 established West Midlands blood donors with at least one negative HCV antibody screen, 43 had seroconverted in 1994 according to the(More)
BACKGROUND Understanding of the epidemiology and natural history of hepatitis C virus (HCV) infection is incomplete without reference to the early phase of infection. The prevalence of HCV infection is well documented in numerous reports. The seroconversion pattern in previously antibody-negative blood donors provides a model for the study of the incidence(More)
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