Learn More
Early diagnosis is a prerequisite for a successful treatment of complex regional pain syndrome (CRPS). In order to describe neurological symptoms which characterize CRPS, we evaluated 145 patients prospectively. Two-thirds of these were women, the mean age at time of investigation was 50.4 years. CRPS followed limb trauma, surgery and nerve lesion.(More)
Complex regional pain syndrome (CRPS) is characterized by a variety of clinical features including spontaneous pain and hyperalgesia. Increased neuropeptide release from peripheral nociceptors has been suggested as a possible pathophysiologic mechanism triggering the combination of trophic changes, edema, vasodilatation and pain. In order to verify the(More)
OBJECTIVE To test the contribution of neurogenic inflammation and neuropeptide release to the pathophysiology of complex regional pain syndrome (CRPS). BACKGROUND CRPS is characterized by edema and increased skin temperature, sympathetic dysfunction and pain, or hyperalgesia. This investigation was prompted by a recent study by the authors that suggested(More)
The aim of this study was to investigate the role of local acidosis in the generation of pain in complex regional pain syndrome (CRPS). We investigated ten patients with CRPS of the upper extremity with a mean duration of the disease of 43 weeks (range 4-280 weeks) and ten control subjects for sensitivity to infusion of fluids with low pH (pH 6.1). Another(More)
To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L;(More)
Idiopathic Parkinson's disease (IPD) is a neurodegenerative disorder of unknown aetiology. Several antigens have been associated with IPD using serological methods. We systematically analysed HLA class I and II alleles in 45 German Caucasian IPD patients using sequence-specific oligonucleotides and sequence-specific primer technology. Applying Bonferroni(More)
The authors investigated 17 patients with idiopathic intracranial hypertension (IIH), correlating laser scanning tomography of the optic nerve with CSF opening pressure. The decrease in papilla volume and papilla height showed a linear correlation with the opening pressure of the CSF (r = 0.59, p < 0.001; r = 0.63, p < 0.001). If the CSF opening pressure is(More)
tain antibodies play a role by recruiting macrophages to the muscle in an ADCC process, remains unclear. In uncontrolled studies, PM and DM respond to prednisone to some degree and for some period of time; adding an immuno-suppressive drug (Azathioprine, Cyclosporine, Mycophenolate, Methotrexate) may have a steroid-sparing effect but their benefit is(More)
Complex regional pain syndrome - in the past called sympathetic reflex dystrophy - is, in its pathophysiology, still not fully understood. However, research in the last few years has led to a better understanding of the illness and the beginning of a pathophysiologically- orientated therapy. The core hypothesis is based on neuropeptide release, neurogenic(More)
This case of osteoid osteoma is reported for two reasons. First, for its rarity and unusual location (it was diagnosed very late) and second because it demonstrates that the history of a painful condition leads to the correct diagnosis, and although clinical investigations may provide corroboratory evidence, they are certainly no substitute. A 23-year-old(More)