M. A. Tavares Cardoso

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Micronization of minocycline hydrochloride dissolved in ethanol and with supercritical carbon dioxide as antisolvent was successfully performed using a recently built SAS apparatus. Amorphous particles of minocycline ranging from 100 to 1000 nm (depending on the operating conditions) were obtained. The mean particle size and the particle size distribution(More)
The use of enzymes in supercritical CO(2) (SCCO(2)) has received extensive attention in recent years. Biocatalysts have the advantage of substrate specificity and SCCO(2) offers several advantages over liquid solvents. This work deals with the utilization of SCCO(2) as a medium for the enzymatic removal of phenol from aqueous solutions using tyrosinase.(More)
Supercritical fluid extraction of the volatile oil of the aerial part of the winter savory was carried out in different conditions of pressure, temperature, mean particle size and CO 2 flow rate and the results were compared with those obtaining by hydrodistillation with a Clevenger-type apparatus. The non-volatile components were extracted by SFE at higher(More)
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