Learn More
We evaluated the antitumor effects of ionizing radiation and tumor necrosis factor-α (TNF-α) gene therapy in human malignant glioma (D54) xenografts. An adenoviral vector (Ad5) containing DNA sequences of the Egr-1 promoter was linked to a cDNA encoding the TNF-α gene (Ad.Egr-TNF). Athymic nude mice bearing D54 xenografts received intratumoral injections of(More)
In this case report, we evaluate the efficacy of allogeneic bone marrow transplantation (BMT) in a 7-month-old female with the infantile form of Alexander’s disease. Based on research that describes Alexander’s disease as a leukodystrophy which may result from an unidentified enzyme deficiency, we attempted marrow transplantation to reverse or arrest the(More)
  • 1