M A Musgrave

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Induction of long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is dependent on N-methyl-D-aspartate (NMDA) receptor activation. However, NMDA receptor stimulation alone is not adequate to trigger LTP. Results from the present study indicate that, in addition to NMDA receptors, there is a requirement for(More)
Unilateral manipulations of frontocortical dopamine have been found in previous studies to produce a directional bias in the circling behaviour of rats. Agonists produced contralateral circling and antagonists produced ipsilateral turning. To examine the role of dopamine receptor subtypes, the present studies investigated the ability of unilateral(More)
Isolated fourth ventricles were diagnosed by computed tomography (CT) in 16 children in a 3 year period. They all had had shunting of the lateral ventricles for hydrocephalus, and all needed subsequent shunt revisions. Seven patients without signs of raised intracranial pressure clinically had new posterior fossa signs at different intervals after lateral(More)
To determine the subcellular distribution of cyclic AMP-coupled metabotropic glutamate receptors (mGluRs), the effects of glutamate agonists on adenylyl cyclase activity were examined using two hippocampal membrane preparations. These were synaptosomes (SY), which are composed of presynaptic terminals, and synaptoneurosomes (SN), which are composed of both(More)
1-Aminocyclopentane-trans-1S,3R-dicarboxylic acid (1S,3R-ACPD), a compound which selectively activates a metabotropic glutamate receptor (mGluR), suppresses hippocampal excitatory synaptic transmission. This depression is not antagonizable by L-2-amino-3-phosphonoproprionic acid (L-AP3), an agent which counteracts mGluR-induced phosphoinositide (PI)(More)
Low doses of ethanol increase responding for brain stimulation. Recently, other intoxicating effects of ethanol have been reversed by the imidazobenzodiazepine, Ro 15-4513. Possibly, Ro 15-4513 blockade also acts on reward-enhancing properties of ethanol. Rats trained to alternately shuttle between nose poke and lever operanda for rewarding stimulation to(More)
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