M. A. Kisel’

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The hemolytic activity of hexadecylphosphocholine (HePC) included in liposomes of phosphatidylcholine (PC), phosphatidylethanol (PET), and their mixture in various ratios has been studied. Spectroscopic data suggest that supramolecular particles containing less than 15% HePC occur as liposomes. Hemolysis at the same HePC concentration is less pronounced for(More)
The toxicity of sterically stabilized doxorubicin-containing “solid” liposomes comprising a mixture of distearoyl analogs of phospatidylcholine and phosphatidylethanol (in a 3: 2 molar ratio) was evaluated. Upon infusion of the ordinary and liposomal doxorubicin in a total dose of 12 mg/kg, the early loss of mice with implanted ascitic Ehrlich’s carcinoma(More)
N-Arachidonoyl (AA) derivatives of amino acids (glycine, phenylalanine, proline, valine, γ-aminobutyric acid (GABA), dihydroxyphenylalanine, tyrosine, tryptophan, and alanine) and peptides (Semax, MEHFPGP, and PGP) were synthesized in order to study the biological properties of acylamino acids. The mass spectra of all the compounds at atmospheric pressure(More)
The effect of phosphatidylethanol (PE) anions on the incorporation of doxorubicin into liquid crystal liposomes consisting of soybean phosphatidylcholine (PC) was studied. Over 90% of the antibiotic are encapsulated in liposomes in the case of a PC/PE = 3: 2 molar ratio, with a doxorubicin content reaching 130 μg/(mg phospholipids). The Stokes radius of the(More)
Doxorubicin has been encapsulated into “solid” liposomes composed of a mixture of distearoyl analogs of phosphatidylcholine and phosphatidylethanol (in a 3: 2 molar ratio). The liposomes are sterically stabilized by incorporating a conjugate of dipalmitoylphosphatidylethanolamine with poly(ethylene glycol)-2000 in an amount of 5 wt % with respect to the(More)
The effect of the structure of the phospholipid substrate on the yield of phosphatidyl-5′-thymidine by transphosphatidylation catalyzed by phospholipase D from Streptomyces netropsis was studied. The reaction and product yield depended on the structures of the polar and nonpolar parts, the hydrophobic-hydrophilic balance, and the degree of unsaturation of(More)
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