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We demonstrate a monolithic photonic integration platform that leverages the existing state-of-the-art CMOS foundry infrastructure. In our approach, proven XeF 2 post-processing technology and compliance with electronic foundry process flows eliminate the need for specialized substrates or wafer bonding. This approach enables intimate integration of large(More)
There is increasing evidence for the role of the autonomic nervous system in the control of adrenal cortical function although the nature of the innervation is as yet unknown. In view of our expanding knowledge of the roles which peptidergic putative transmitters play in the autonomic nervous system, the present study was adrenal gland. Using(More)
Using in vitro autoradiography, 125I-VIP binding was found to be concentrated in the capsule and glomerulosa of the rat adrenal cortex. The densest receptor distribution was coincident with the distribution of VIP nerve fibers that arborize extensively in the capsule and glomerulosa. The specificity of this binding was demonstrated using unlabelled VIP,(More)
There is now convincing evidence for the distribution of several nerve plexuses in the outer zone of the adrenal cortex. At the ultrastructural level, the close proximity of nerve boutons to cortical cells establishes the anatomical substrate for a direct neural effect on adrenal cortical cell functions. Of those neurotransmitters and neuropeptides(More)
Previous results from this laboratory have suggested that neurons in the ventrolateral medulla (VLM) modulate the pressor response to muscular contraction. The purpose of the present study was to determine 1) if VLM neurons with a discharge pattern related to sympathetic discharge and/or the cardiac cycle are stimulated during muscular contraction, 2) if(More)
Regeneration of rat adrenals was studied after bilateral enucleation to determine whether there is a neural component mediating this process as there is in compensatory adrenal growth after unilateral adrenalectomy. Regeneration was approximately 50% complete (based on criteria of wet weight and DNA content) by 10 days after enucleation; at this time(More)
Immunoreactive serotonin is demonstrated to be present in 75% of rat adrenal medullary cells using an antibody to serotonin and peroxidase-antiperoxidase immunocytochemical method. The concentration of serotonin in rat adrenals was found to be 7.7 +/- 0.1 X 10(-6) mol/kg wet weight by high-performance liquid chromatography with electrochemical detection.(More)
BACKGROUND A reduction in gamma-aminobutyric (GABA)-mediated inhibition of pressor sites in the caudal hypothalamus of spontaneously hypertensive rats compared with that of normotensive Wistar-Kyoto rats has recently been demonstrated. OBJECTIVE To determine whether the reduction in GABA-mediated inhibition of the caudal hypothalamus of the spontaneously(More)
There is experimental evidence suggesting that the interstitial cells of Cajal are essential for rhythmic slow waves of the smooth muscle layers of the mammalian small intestine. Different investigators have identified them variously as modified neurons, glia, fibroblasts or modified smooth muscle cells. Since histological categorization bears on(More)
We previously found serotonin in the adrenal medulla of the rat using immunocytochemical methods. Serotonin immunoreactivity was found in 75% of the medullary cells and by double staining techniques was found to be present in epinephrine-containing cells. In order to better understand the chemical and pharmacological nature of the adrenomedullary serotonin(More)