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OBJECTIVE To discuss the proper methods used to elicit the Hoffmann reflex (H-reflex) and to present different situations in which this tool can be used in sports medicine research. DATA SOURCES We searched MEDLINE and SPORT Discus from 1960 to 2004 using the key words Hoffmann reflex, H-reflex, and methodology. The remaining citations were collected from(More)
von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome that is characterized by the development of multiple vascular tumors and is caused by inactivation of the von Hippel-Lindau protein (pVHL). Here we show that pVHL, through its beta-domain, binds directly to hypoxia-inducible factor (HIF), thereby targeting HIF for ubiquitination in an(More)
OBJECTIVE To determine whether a difference in unilateral postural stability exists between the functionally dominant and nondominant legs of a healthy population. DESIGN AND SETTING The unilateral postural control of both legs of healthy subjects was tested using a force plafform. Before the postural control examination, each subject performed a series(More)
The Hoffman reflex (H-reflex) has been widely used throughout neuroscience research, as it allows for the assessment of alpha motoneuron excitability arising from a specific motoneuron pool. Recently, a protocol has been developed allowing for the simultaneous examination of the soleus, peroneal, and tibialis anterior motoneuron pools elicited from a single(More)
The integration of patient-specific genomic information into the electronic medical record (EMR) will create many opportunities to improve patient care. Key to the successful incorporation of genomic information into the EMR will be the development of laboratory information systems capable of appropriately formatting molecular diagnostic and cytogenetic(More)
OBJECTIVE To investigate the reliability of a newly developed perturbation protocol for assessing dynamic balance. DESIGN Each subject was tested in two experimental balance conditions, static and dynamic. The dependent variables for the static condition were sway area (SA), sway path length (SPL), sagittal sway standard deviation (SSD), and lateral sway(More)
The purpose of this research was to compare the effects of a warm-up with static vs. dynamic stretching on countermovement jump (CMJ) height, reaction time, and low-back and hamstring flexibility and to determine whether any observed performance deficits would persist throughout a series of CMJs. Twenty-one recreationally active men (24.4 ± 4.5 years)(More)
This study evaluated the additive effects of hormone replacement therapy (HRT) and a 1-year site-specific resistance-training (RT) program involving two free weight exercises (i.e., squat and deadlift) 2 days/week as a strategy to reverse or attenuate bone loss at the lumbar spine in early postmenopausal women. Participants from a group of self-selected HRT(More)
During explosive movements and potentially injurious situations, the ability to rapidly generate torque is critical. Previous research has suggested that different phases of rate of torque development (RTD) are differentiately controlled. However, the extent to which supraspinal and spinal mechanisms predict RTD at different time intervals is unknown. RTD(More)