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OBJECTIVE To discuss the proper methods used to elicit the Hoffmann reflex (H-reflex) and to present different situations in which this tool can be used in sports medicine research. DATA SOURCES We searched MEDLINE and SPORT Discus from 1960 to 2004 using the key words Hoffmann reflex, H-reflex, and methodology. The remaining citations were collected from(More)
This study evaluated the additive effects of hormone replacement therapy (HRT) and a 1-year site-specific resistance-training (RT) program involving two free weight exercises (i.e., squat and deadlift) 2 days/week as a strategy to reverse or attenuate bone loss at the lumbar spine in early postmenopausal women. Participants from a group of self-selected HRT(More)
von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome that is characterized by the development of multiple vascular tumors and is caused by inactivation of the von Hippel-Lindau protein (pVHL). Here we show that pVHL, through its beta-domain, binds directly to hypoxia-inducible factor (HIF), thereby targeting HIF for ubiquitination in an(More)
OBJECTIVE To investigate quadriceps strength and static and dynamic balance in the anterior cruciate ligament (ACL)-reconstructed patient and to compare these findings with an age-matched, injury-free control group. DESIGN AND SETTING A 2 x 2 mixed-design analysis of variance (group x leg) was applied to the static posture, dynamic balance, and strength(More)
OBJECTIVE To determine whether a difference in unilateral postural stability exists between the functionally dominant and nondominant legs of a healthy population. DESIGN AND SETTING The unilateral postural control of both legs of healthy subjects was tested using a force plafform. Before the postural control examination, each subject performed a series(More)
PURPOSE To determine the response rate to 2-chlorodeoxyadenosine (2-CdA; cladribine) in patients with advanced indolent non-Hodgkin's lymphoma (NHL) who fail to respond to or progress after a response to standard chemotherapy drugs. PATIENTS AND METHODS Twenty-one patients were treated with at least one cycle of 2-CdA 0.1 mg/kg/d by continuous infusion(More)
Interferon-alpha (IFN alpha) increases the cytotoxicity of 5-fluorouracil (FUra) in vitro, and the combination has clinical efficacy against advanced colorectal cancer. IFN alpha treatment of HT-29 colon carcinoma cells induced a greater than two-fold increase in the intracellular levels of the active metabolite of FUra, FdUMP. Using cell extracts from(More)
The integration of patient-specific genomic information into the electronic medical record (EMR) will create many opportunities to improve patient care. Key to the successful incorporation of genomic information into the EMR will be the development of laboratory information systems capable of appropriately formatting molecular diagnostic and cytogenetic(More)
Numerous questions exist regarding the utilization of sensory information for postural control. Past research has established the possibility that cognitive tasks requiring visual perception may affect the processing of visual information used for postural control. The purpose of this study was two fold: (1) to investigate the effects of varying demands of(More)
The Hoffman reflex (H-reflex) has been widely used throughout neuroscience research, as it allows for the assessment of alpha motoneuron excitability arising from a specific motoneuron pool. Recently, a protocol has been developed allowing for the simultaneous examination of the soleus, peroneal, and tibialis anterior motoneuron pools elicited from a single(More)