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OBJECTIVE Because clinical data about the therapeutic consequences of polymorphic oxidation of simvastatin by CYP2D6 have not been well reported, we sought to investigate the possible link between polymorphism of CYP2D6 and the efficacy and tolerability of simvastatin treatment in a group of 88 patients with hypercholesterolemia. METHODS The CYP2D6(More)
AIM The beta 3-adrenergic receptor (beta 3-AR) is suspected to play a key role in the regulation of energy balance by increasing lipolysis and thermogenesis. A mutation in the beta 3-AR gene (Trp64Arg) has been associated with the capacity of weight gain and with early onset of noninsulin dependent diabetes mellitus (type 2 diabetes). In this study we(More)
Brain tissue of 50 patients with morphological con®rmed Parkinson's disease (PD), blood samples from 149 patients with clinical parkinsonism and from 96 healthy control subjects were collected. Apolipoprotein-E (apo E) and cyto-chrome P450 2D6 (CYP2D6) genotyping were performed by PCR followed by restriction fragment analysis. A signi®cantly higher allele(More)
The purpose of the study was to investigate the relationships between some psychological characteristics and blood pressure. We used the Bestiary Test which gives an impression of the child's psychological characteristics and his way of coping with personal conflicts. The test was applied to 766 children between the ages of 4-10 years. By discriminant(More)