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Correspondence to: Professor P N Leigh, King’s MND Care and Research Centre, Department of Neurology, Institute of Psychiatry and Guy’s King’s and St Thomas’s School of Medicine, PO Box 41, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK; n.leigh@iop.kcl.ac.uk _________________________ T he management of motor neurone disease (MND) has evolved(More)
BACKGROUND/AIMS We aimed to estimate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in the South East of England. The reported incidence of ALS varies between 0.44 and 3.2 per 100,000 person years. This can partly be explained by differences in design and diagnostic criteria used. There is little population data concerning England,(More)
OBJECTIVE We sought to define the significance of brachial amyotrophic diplegia (flail arm syndrome [FA]) and the pseudopolyneuritic variant (flail leg syndrome [FL]) of amyotrophic lateral sclerosis (ALS; motor neuron disease). METHODS We analyzed survival in clinic cohorts in London, UK (1,188 cases), and Melbourne, Australia (432 cases). Survival from(More)
BACKGROUND Motor neurone disease (MND) is a progressive neurodegenerative disease leading to limb weakness, wasting and respiratory failure. Prolonged poor nutritional intake causes fatigue, weight loss and malnutrition. Consequently, disease progression requires decisions to be made regarding enteral tube feeding. The present study aimed to investigate the(More)
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