M. A. Adamchak

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In our search for novel dual inhibitors of cyclooxygenase and 5-1ipoxygenase, a series of 3,5-di-tbutyl-styryl heterocycles have been identified. These compounds are active in a variety of models of inflammation and are nonulcerogenic in rats. Of these compounds, 2,6-bis(l, 1 -dimethylethyl)-4[2-(5-methyl1//-pyrazol-3-yl)ethenyl]phenol (PD 127443) was the(More)
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