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Impaired Function of HDAC6 Slows Down Axonal Growth and Interferes with Axon Initial Segment Development
TLDR
The results reveal a new role of HDAC6 tubulin deacetylase as a regulator of microtubule characteristics in the axon distal region where axonal elongation takes place, and allowing the development of acetylated microtubules microdomains whereHDAC6 is not concentrated.
Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation
TLDR
A crosstalk between two metabotropic and one ionotropic purinergic receptor that regulates cAMP levels through adenylate cyclase 5 and modulates axonal elongation triggered by neurotropic factors and the PI3K–Akt–GSK3 pathway is demonstrated.
The role of axonal Kv1 channels in CA3 pyramidal cell excitability
TLDR
Kv1 channels located in the axon proper greatly participate in intrinsic excitability of CA3 pyramidal neurons, stressing the importance of the axonal compartment in the regulation of intrinsic neuronal excitability.
Topological Information Data Analysis
TLDR
Methods that quantify the structure of statistical interactions within a given data set, and propose that higher-order statistical interactions and non-identically distributed variables are constitutive characteristics of biological systems that should be estimated in order to unravel their significant statistical structure and diversity are presented.
GSK3 and β-catenin determines functional expression of sodium channels at the axon initial segment
TLDR
The results suggest a mechanism for the modulation of neuronal excitability through the control of sodium channel density by GSK3 and β-catenin at the AIS.
Cannabinoid Receptors Modulate Neuronal Morphology and AnkyrinG Density at the Axon Initial Segment
TLDR
The data suggest that neuronal CB1R basal activity plays a role in initial development of dendrites and indirectly in AIS proteins accumulation, which indirectly determines the accumulation of ankyrinG and AIS development.
Robustness to Axon Initial Segment Variation Is Explained by Somatodendritic Excitability in Rat Substantia Nigra Dopaminergic Neurons
TLDR
Large cell-to-cell variations in AIS length or distance from the soma in rat substantia nigra pars compacta dopaminergic neurons are described and it is found that AP shape and pacemaking frequency were independent of AIS geometry.
Diversity of Axonal and Dendritic Contributions to Neuronal Output
TLDR
This article presents a few examples of “misbehaving” neurons (with a non-canonical polarity scheme) to highlight the diversity of solutions that are used by mammalian neurons to transmit information.
Neurotransmitter identity and electrophysiological phenotype are genetically coupled in midbrain dopaminergic neurons
Most neuronal types have a well-identified electrical phenotype. It is now admitted that a same phenotype can be produced using multiple biophysical solutions defined by ion channel expression
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