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Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes.

• María Yáñez-Mó, Olga Barreiro, Mónica Gordón-Alonso, Mónica Sala-Valdés, Francisco Sánchez-Madrid
• Trends in cell biology
• 2009

Membrane lipids and proteins are non-randomly distributed and are unable to diffuse freely in the plane of the membrane. This is because of multiple constraints imposed both by the cortical… (More)

Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation.

• Olga Barreiro, María Yáñez-Mó, +6 authors Francisco Sánchez-Madrid
• Blood
• 2005

Tetraspanins associate with several transmembrane proteins forming microdomains involved in intercellular adhesion and migration. Here, we show that endothelial tetraspanins relocalize to the contact… (More)

Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular…

• Sonia López-Giral, Nuria E Quintana, +6 authors Cecilia Muñoz
• Journal of leukocyte biology
• 2004

B cell neoplasms present heterogeneous patterns of lymphoid organ involvement, which may be a result of the differential expression of chemokine receptors. We found that chemokine receptor (CCR)7,… (More)

MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells.

• María Yáñez-Mó, Olga Barreiro, +10 authors Francisco Sánchez-Madrid
• Blood
• 2008

MT1-MMP plays a key role in endothelial function, as underscored by the angiogenic defects found in MT1-MMP deficient mice. We have studied the molecular interactions that underlie the functional… (More)

Effect of an anti-human Co-029/tspan8 mouse monoclonal antibody on tumor growth in a nude mouse model

• Naouel Ailane, C Greco, +7 authors Claude Boucheix
• Front. Physiol.
• 2014

New therapeutic agents are needed in digestive tract tumors. Co-029/tspan8 is a tetraspanin frequently expressed on human colorectal tumors, In this work, we report the effects of the monoclonal… (More)

Multi-factorial modulation of colorectal carcinoma cells motility – partial coordination by the tetraspanin Co-029/tspan8

• Yingying Zhu, Naouel Ailane, +8 authors Céline Greco
• Oncotarget
• 2017

Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing cells infected by mycoplasmas and mycoplasmas free… (More)

Targeting tetraspanins in cancer.

• Mónica Sala-Valdés, Naouel Ailane, Céline Greco, Eric Rubinstein, Claude Boucheix
• Expert opinion on therapeutic targets
• 2012

INTRODUCTION Tetraspanins are a family of small proteins that cross the membrane four times and form complexes by interacting between themselves and with a variety of transmembrane and cytosolic… (More)

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia

• Maribel Forero-Castro, Cristina Robledo, +25 authors Jesus M. Hernandez-Rivas
• British Journal of Cancer
• 2017

Background:In B-cell precursor acute lymphoblastic leukaemia (B-ALL), the identification of additional genetic alterations associated with poor prognosis is still of importance. We determined the… (More)

Conexiones de los Microdominios de Tetraspaninas con el citoesqueleto de actina y su función en los procesos de Migración y Sinapsis Inmune

• Mónica Sala-Valdés
• 2010

Las tetraspaninas se caracterizan por su capacidad de interaccionar unas con otras y con otras proteinas organizando en la membrana plasmatica microdominios denominados ?Microdominios ricos en… (More)

El análisis proteómico del interactoma intracelular revela que las tetraspaninas modulan el repertorio de proteínas que forman parte de los exosomas de linfocitos T humanos

• Daniel Pérez-Hernández, Inmaculada Jorge, +4 authors Jesús M. Vázquez
• 2012

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