Mónica Rodríguez-Bolaños

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For a better comprehension of the structure-function relationship in proteins it is necessary to identify the amino acids that are relevant for measurable protein functions. Because of the numerous contacts that amino acids establish within proteins and the cooperative nature of their interactions, it is difficult to achieve this goal. Thus, the study of(More)
to 'Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes'. (c) mutant no. additive mutations in region 2 regions of TcTIM scheme of different amino acids in region 2
The reactivation of triosephosphate isomerase (TIM) from unfolded monomers induced by guanidine hydrochloride involves different amino acids of its sequence in different stages of protein refolding. We describe a systematic mutagenesis method to find critical residues for certain physico-chemical properties of a protein. The two similar TIMs of Trypanosoma(More)
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