Mónica Méndez Díaz

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We have recently cloned a glucose transporter from brown trout muscle (btGLUT) with high sequence homology to mammalian GLUT4 that is predominantly expressed in red and white skeletal muscle, the two major sites of glucose uptake in trout. In order to study the physiological regulation of this putative fish GLUT4, we have investigated the expression of(More)
The existence of sibling species is widespread among nematodes and the recognition of these has important epidemiological implications. In an attempt to establish whether this is the case for Hysterothylacium fabri, which is present in many Mediterranean fish species, we studied its genetic diversity and analysed its population structure. To do this, we(More)
Insulin is an important factor for the maintenance of glucose homeostasis, enhancing glucose uptake in its target tissues in a process that has been conserved between fish and mammals. In fish skeletal muscle cells, like in mammals, insulin promotes GLUT4 translocation to the plasma membrane and, consequently, glucose uptake, but its role regulating the(More)
In mammals, glucose transporter (GLUT)-4 plays an important role in glucose homeostasis mediating insulin action to increase glucose uptake in insulin-responsive tissues. In the basal state, GLUT4 is located in intracellular compartments and upon insulin stimulation is recruited to the plasma membrane, allowing glucose entry into the cell. Compared with(More)
Protein components of the spliceosome are highly conserved in eukaryotes and can influence several steps of the gene expression process. RSR-2, the Caenorhabditis elegans ortholog of the human spliceosomal protein SRm300/SRRM2, is essential for viability, in contrast to the yeast ortholog Cwc21p. We took advantage of mutants and RNA interference (RNAi) to(More)
The glucose transporter 4 (GLUT4) plays a key role in glucose uptake in insulin target tissues. This transporter has been extensively studied in many species in terms of its function, expression and cellular traffic and complex mechanisms are involved in its regulation at many different levels. However, studies investigating the transcription of the GLUT4(More)
Polycyclic aromatic hydrocarbons (PAHs) are pollutants that are potentially carcinogenic, are widely distributed in the environment, and accumulate in soils. The peroxydisulfate anion strategy for the remediation of PAH-contaminated soils has attracted widespread interest, despite its negative effects on soil microbial activity as a result of oxidative(More)
Actualización por temas SUMMARY In this second paper of the Brain, Drugs and Genes review we would like to discuss illicit drugs and the genetics that may predispose subjects to addiction. We describe the effects, action sites and pathophysiological consequences of the use of these illicit drugs. The drugs that are reviewed are marijuana, heroin, cocaine,(More)
SUMMARY Eating is a behavior addressed to get the necessary energy for the organism to survive and to contend with the demands of its environment. Since our organism evolved within an environment lacking food, the genes that adapted us to the environment were those that promote the storage and optimization of nutrients, as well as those that evoke the skill(More)
SUMMARY Eating is a behavior oriented to get the energy necessary for the organism to survive and to contend with the demands of its environment. Food, besides of energy, provides structure and function, as amino acids are converted into structural or secretion proteins or enzymes. These proteins are synthesized following a strict genetic code. Variants in(More)