Mélisande Bourgoin-Heck

  • Citations Per Year
Learn More
Asthma is a heterogeneous disease characterized by numerous phenotypes relating to age of onset, triggers, comorbidities, severity (assessed by multiple exacerbations, lung function pattern) and finally the inflammatory cells involved in the pathophysiologic pathway. These phenotypes can vary over time in relation to changes in the principal triggers(More)
BACKGROUND Hyperbilirubinemia (HB) occurs in 90% of preterm newborns. HB induces acute neurological disorders (somnolence, abnormal tone, feeding difficulties, auditory dysfunction) and alterations in respiratory control. These findings suggest brainstem neurotoxicity that could also affect swallowing centers. OBJECTIVE To test the hypothesis that HB(More)
Authors declare no relevant conflicts of interest related to the present work. Severe eosinophilic non-allergic asthma is a rare phenotype that could be effectively treated by omalizumab, especially when associated with elevated total serum IgE and nasal polyposis. Severe eosinophilic non-allergic asthma is a specific phenotype, rarely described in(More)
BACKGROUND Childhood recurrent wheezing and consequently asthma corresponds to various phenotypes. Our aim was to link genetic variants of asthma candidate genes to the phenotypes of early onset wheezing. STUDY DESIGN We included very young consecutive children presenting with recurrent wheezing who had been evaluated for the severity of wheezing,(More)
Hyperbilirubinemia (HB) occurs in 90% of preterm newborns. Moderate HB can induce acute neurological disorders while severe HB has been linked to a higher incidence of apneas of prematurity. The present study aimed to test the hypothesis that even moderate HB disrupts cardiorespiratory control in preterm lambs. Two groups of preterm lambs (born 14 days(More)
  • 1