Mélanie Tannières

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Recent basic knowledge on the regulation of virulence in pectinolytic bacteria revealed pathogen communication via quorum sensing signals as a crucial event for the expression of virulence and the onset of disease symptoms. In this paper, we present and discuss advances in a new biocontrol approach based on the interference of microbial communication(More)
Quorum-sensing (QS) signals of the N-acylhomoserine lactone (NAHL) class are cleaved by quorum-quenching enzymes, collectively named NAHLases. Here, functional metagenomics allowed the discovery of a novel bacterial NAHLase in a rhizosphere that was treated with γ-caprolactone. As revealed by rrs-DGGE and rrs-pyrosequencing, this treatment increased the(More)
N-acylhomoserine lactone (AHL)-mediated quorum-sensing (QS) regulates virulence functions in plant and animal pathogens such as Agrobacterium tumefaciens and Pseudomonas aeruginosa. A chemolibrary of more than 3500 compounds was screened using two bacterial AHL-biosensors to identify QS-inhibitors (QSIs). The purity and structure of 15 QSIs selected through(More)
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