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Degradation of Cellular miR-27 by a Novel, Highly Abundant Viral Transcript Is Important for Efficient Virus Replication In Vivo
Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murineExpand
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  • Open Access
Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a numberExpand
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  • Open Access
Deregulation of Type I IFN-Dependent Genes Correlates with Increased Susceptibility to Cytomegalovirus Acute Infection of Dicer Mutant Mice
Regulation of gene expression by microRNAs (miRNAs) is now considered as an essential mechanism for cell development and homeostasis. Indeed, numerous studies have reported that modulating theirExpand
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  • Open Access
Antiviral RNA interference in animals: piecing together the evidence
RNA interference (RNAi) is a powerful mechanism to fight viral infections in plants and invertebrates. Two recent reports provide new, compelling evidence for a functional role for antiviral RNAi inExpand
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An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans
ABSTRACT Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STATExpand
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  • Open Access
Formation of large viroplasms and virulence of Cauliflower mosaic virus in turnip plants depend on the N-terminal EKI sequence of viral protein TAV
Cauliflower mosaic virus (CaMV) TAV protein (TransActivator/Viroplasmin) plays a pivotal role during the infection cycle since it activates translation reinitiation of viral polycistronic RNAs andExpand
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  • Open Access
An alternative STAT signaling pathway acts in antiviral immunity in Caenorhabditis elegans
Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STATExpand
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Regulation of cellular and viral microRNAs accumulation upon mouse cytomegalovirus infection
Les virus de la famille des herpesviridae, tels que le cytomegalovirus murin (MCMV), peuvent exprimer leurs propres micro-(mi)ARN, ils sont egalement capables de dereguler l’expression des miARNExpand