Mélanie Saint-Jean

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BACKGROUND Research is needed to evaluate the efficacy of prevention and treatment for post-partum depression. METHOD Subjects were screened with the Edinburgh Post-natal Depression Scale (EPDS) at the obstetric clinic. Mothers at risk (N = 258) (EPDS scores > or = 9) were randomly assigned to a prevention/treatment group or a control group. The(More)
37 children presenting with West's syndrome were studied by computerized tomography scanning. An abnormality consisting of diffuse cerebral atrophy, predominating in the fronto-temporal region, was demonstrated in 30 cases. The abnormality was sometimes associated with calcification (tuberous sclerosis) or malformation (agenesis of the corpus callosum). The(More)
  • J Lambert, G De Loubens, T Mélin, C Guthmann, M Saint-Jean
  • 2003
– We report the observation in the direct space of the transport of a few thousand charges submitted to a tunable electric field along the surface of a silicon oxide layer. Charges are both deposited and observed using the same Electrostatic Force Microscope. During the time range accessible to our measurements (i.e. t = 1 ∼ 1000 s), the transport of(More)
Vemurafenib is indicated for the treatment of patients with BRAF (V600)-mutant metastatic melanoma. We studied for the first time the characteristics of brain metastases developed during treatment with vemurafenib in real-life conditions. We included all patients treated over 3 years with vemurafenib in our department for metastatic melanoma without initial(More)
While treating stage III melanoma patients with autologous therapeutic TIL in an adjuvant setting, we previously reported a significant benefit of treatment on both progression-free survival and overall survival in patients with only one invaded lymph node (early stage III) compared to patients with more than one invaded lymph nodes (advanced stage III). In(More)
High resistance rate of melanoma to chemotherapy results in the development of other therapeutic strategies such as immunotherapy. Discrepancies observed in clinical responses to immunotherapy suggest the presence of immune polymorphisms and tumor escape mechanisms. The objective of this study was to investigate the expression of B7-H3 and B7-H4 which are(More)
The authors have reported a case of cerebral lipidosis (type Jansky-Bielschowsky) in which the presenting features appeared at the age of 2 years 10 months, and consisted of clonic seizures followed by atonic attacks and atypical absences. The association of seizures, severe mental disturbances and EEG abnormalities with an interseizure abnormality (diffuse(More)