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Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.

• Mélanie Lalancette-Hébert, Genevieve Gowing, Alain R Simard, Yuan Weng, J. Stanley Kriz
• The Journal of neuroscience : the official…
• 2007

Here we report in vivo evidence of a neuroprotective role of proliferating microglial cells in cerebral ischemia. Using transgenic mice expressing a mutant thymidine kinase form of herpes simplex… (More)

Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation.

• Mélanie Lalancette-Hébert, Denis Phaneuf, Geneviève Soucy, Y. C. Weng, J. Kriz
• Brain : a journal of neurology
• 2009

Activation of microglial cells in response to ischaemic injury, inflammatory and/or immune stimuli is associated with the marked induction of Toll-like receptor 2 (TLR2). At present, little is known… (More)

Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury.

• Mélanie Lalancette-Hébert, Vivek Swarup, +5 authors J. Stanley Kriz
• The Journal of neuroscience : the official…
• 2012

Growing evidence suggests that galectin-3 is involved in fine tuning of the inflammatory responses at the periphery, however, its role in injured brain is far less clear. Our previous work… (More)

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.

• Tomohiro Yamazaki, Shi Chen, +16 authors Robin Reed
• Cell reports
• 2012

Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder… (More)

Inflammation, plasticity and real-time imaging after cerebral ischemia

• J. Stanley Kriz, Mélanie Lalancette-Hébert
• Acta Neuropathologica
• 2009

With an incidence of approximately 350 in 100,000, stroke is the third leading cause of death and a major cause of disability in industrialized countries. At present, although progress has been made… (More)

Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage.

• Mélanie Lalancette-Hébert, Carl Julien, +4 authors J. Stanley Kriz
• Stroke
• 2011

BACKGROUND AND PURPOSE Consumption of fish has been shown to reduce risk of coronary heart disease and, possibly, of ischemic stroke. Because docosahexaenoic acid (DHA) is the most likely neuroactive… (More)

Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.

• Genevieve Gowing, Mélanie Lalancette-Hébert, Jean-Nicolas Audet, Florence Dequen, Jean-Pierre Julien
• Experimental neurology
• 2009

Macrophage colony stimulating factor (M-CSF) is a cytokine that regulates the survival, proliferation and maturation of microglial cells. Administration of M-CSF can promote neuronal survival in… (More)

Impact of the loss of Hoxa5 function on lung alveogenesis.

• Isabel Mandeville, Josée Aubin, +4 authors Lucie Jeannotte
• The American journal of pathology
• 2006

The involvement of genes controlling embryonic processes in the etiology of diseases often escapes attention because of the focus given to their inherent developmental role. Hoxa5 belongs to the Hox… (More)

Microglial response to gold nanoparticles.

• Eliza Hutter, S Boridy, +4 authors Dusica Maysinger
• ACS nano
• 2010

Given the emergence of nanotherapeutics and nanodiagnostics as key tools in today's medicine, it has become of critical importance to define precisely the interactions of nanomaterials with… (More)

The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis.

• François C Chouinard, Julie Lefebvre, +6 authors Nicolas Flamand
• Journal of immunology
• 2011

Although endocannabinoids are important players in nociception and obesity, their roles as immunomodulators remain elusive. The main endocannabinoids described to date, namely 2-arachidonoyl-glycerol… (More)

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